The Phospho-ACTH (S168) Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to Alpha MSH, Beta Endorphin, NPP, POC, POMC, proopiomelanocortin, and Beta MSH. This antibody recognizes Human antigen. The Phospho-ACTH (S168) Antibody has been validated for the following applications: Dot Blot, and ELISA.
Description
This gene encodes a polypeptide hormone precursor that
undergoes extensive, tissue-specific, post-translational processing
via cleavage by subtilisin-like enzymes known as prohormone
convertases. There are eight potential cleavage sites within the
polypeptide precursor and, depending on tissue type and the
available convertases, processing may yield as many as ten
biologically active peptides involved in diverse cellular
functions. The encoded protein is synthesized mainly in
corticotroph cells of the anterior pituitary where four cleavage
sites are used; adrenocorticotrophin, essential for normal
steroidogenesis and the maintenance of normal adrenal weight, and
lipotropin beta are the major end products. In other tissues,
including the hypothalamus, placenta, and epithelium, all cleavage
sites may be used, giving rise to peptides with roles in pain and
energy homeostasis, melanocyte stimulation, and immune modulation.
These include several distinct melanotropins, lipotropins, and
endorphins that are contained within the adrenocorticotrophin and
beta-lipotropin peptides. Mutations in this gene have been
associated with early onset obesity, adrenal insufficiency, and red
hair pigmentation. Alternatively spliced transcript variants
encoding the same protein have been described. [provided by
RefSeq]